Haemorrhagic septicaemia (HS) is one of the most important bacterial diseases affecting cattle and buffaloes, particularly in tropical and subtropical regions of Asia and Africa. Disease is caused by Pasteurella multocida, and characterized by acute septicaemia, high fever, and respiratory distress, swelling of the throat and neck region, and high mortality. Buffaloes are generally more susceptible than cattle, and outbreaks are often associated with during high humidity, heavy rainfall, transportation stress, poor nutrition, and inadequate management practices. Transmission occurs primarily through direct contact with infected or carrier animals and contaminated feed or water sources. Early diagnosis and proper treatment are important and vaccination is the most effective way for disease prevention and control. Biosecurity at farm, proper nutrition, stress reduction, quarantine of newly introduced animals, and farmer awareness can help to reduce the occurrence of disease. Effective control of Haemorrhagic septicaemia requires coordinated efforts among farmers, veterinarians, researchers, and government agencies.